Specifically Targeting Metacaspases of Candida: A New Therapeutic Opportunity.

ABSTRACT: The World Health Organization (WHO) recently published a list of fungal priority pathogens, including Candida albicans and C. auris. The increased level of resistance of Candida is raising concern, considering the availability of only four classes of medicine. The WHO is seeking novel agent classes with different targets and mechanisms of action. Targeting Candida metacaspases to control intrinsic cell death could provide new therapeutic opportunities for invasive candidiasis. In this review, we provide the available evidence for Candida cell death, describe Candida metacaspases, and discuss the potential of Candida metacaspases to offer a new specific target. Targeting Candida cell death has good scientific rationale given that the f

SUBMITTER: Bienvenu AL 

PROVIDER: S-EPMC10889698 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature