Multiple Lines of Evidence Support 199 SARS-CoV-2 Positively Selected Amino Acid Sites.

ABSTRACT: SARS-CoV-2 amino acid variants that contribute to an increased transmissibility or to host immune system escape are likely to increase in frequency due to positive selection and may be identified using different methods, such as codeML, FEL, FUBAR, and MEME. Nevertheless, when using different methods, the results do not always agree. The sampling scheme used in different studies may partially explain the differences that are found, but there is also the possibility that some of the identified positively selected amino acid sites are false positives. This is especially important in the context of very large-scale projects where hundreds of analyses have been performed for the same protein-coding gene. To account for these issues, in this work, we have identified positively selected amino ac

SUBMITTER: Ferreira P 

PROVIDER: S-EPMC10889775 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature