CHST4 Gene as a Potential Predictor of Clinical Outcome in Malignant Pleural Mesothelioma.

ABSTRACT: Malignant pleural mesothelioma (MPM) develops primarily from asbestos exposures and has a poor prognosis. In this study, The Cancer Genome Atlas was used to perform a comprehensive survival analysis, which identified the CHST4 gene as a potential predictor of favorable overall survival for patients with MPM. An enrichment analysis of favorable prognostic genes, including CHST4, showed immune-related ontological terms, whereas an analysis of unfavorable prognostic genes indicated cell-cycle-related terms. CHST4 mRNA expression in MPM was significantly correlated with Bindea immune-gene signatures. To validate the relationship between CHST4 expression and prognosis, we performed an immunohistochemical analysis of CHST4 protein expression in 23 surgical spec

SUBMITTER: Okado S 

PROVIDER: S-EPMC10889779 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature