Trained Innate Immunity in Animal Models of Cardiovascular Diseases.

ABSTRACT: Acquisition of immunological memory is an important evolutionary strategy that evolved to protect the host from repetitive challenges from infectious agents. It was believed for a long time that memory formation exclusively occurs in the adaptive part of the immune system with the formation of highly specific memory T cells and B cells. In the past 10-15 years, it has become clear that innate immune cells, such as monocytes, natural killer cells, or neutrophil granulocytes, also have the ability to generate some kind of memory. After the exposure of innate immune cells to certain stimuli, these cells develop an enhanced secondary response with increased cytokine secretion even after an encounter with an unrelated stimulus. This phenomenon has been termed trained innate immunity (TI) and is

SUBMITTER: Kleimann P 

PROVIDER: S-EPMC10889825 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature