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Carneusones A-F, Benzophenone Derivatives from Sponge-Derived Fungus Aspergillus carneus GXIMD00543.

ABSTRACT: Six benzophenone derivatives, carneusones A-F (1-6), along with seven known compounds (7-13) were isolated from a strain of sponge-derived marine fungus Aspergillus carneus GXIMD00543. Their chemical structures were elucidated by detailed spectroscopic data and quantum chemical calculations. Compounds 5, 6, and 8 exhibited moderate anti-inflammatory activity on NO secretion using lipopolysaccharide (LPS)-induced RAW 264.7 cells with EC₅₀ values of 34.6 ± 0.9, 20.2 ± 1.8, and 26.8 ± 1.7 μM, while 11 showed potent effect with an EC₅₀ value of 2.9 ± 0.1 μM.

SUBMITTER: Lu CJ

PROVIDER: S-EPMC10890008 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Carneusones A-F, Benzophenone Derivatives from Sponge-Derived Fungus Aspergillus carneus GXIMD00543.

Lu Chun-Ju CJ Liang Li-Fen LF Zhang Geng-Si GS Li Hai-Yan HY Fu Chun-Qing CQ Yu Qin Q Zhou Dong-Mei DM Su Zhi-Wei ZW Liu Kai K Gao Cheng-Hai CH Xu Xin-Ya XY Liu Yong-Hong YH

Marine drugs 20240125 2

Six benzophenone derivatives, carneusones A-F (1-6), along with seven known compounds (7-13) were isolated from a strain of sponge-derived marine fungus Aspergillus carneus GXIMD00543. Their chemical structures were elucidated by detailed spectroscopic data and quantum chemical calculations. Compounds 5, 6, and 8 exhibited moderate anti-inflammatory activity on NO secretion using lipopolysaccharide (LPS)-induced RAW 264.7 cells with EC ...[more]

PMID: 38393034

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