Superfluorinated, Highly Water-Soluble Polyphosphazenes as Potential ¹⁹F Magnetic Resonance Imaging (MRI) Contrast Agents.

ABSTRACT: "Hot spot" ¹⁹F magnetic resonance imaging (MRI) has garnered significant attention recently for its ability to image various disease markers quantitatively. Unlike conventional gadolinium-based MRI contrast agents, which rely on proton signal modulation, ¹⁹F-MRI's direct detection has a unique advantage in vivo, as the human body exhibits a negligible background ¹⁹F-signal. However, existing perfluorocarbon (PFC) or PFC-based contrast materials suffer from several limitations, including low longitudinal relaxation rates and relatively low imaging efficiency. Hence, we designed a macromolecular contrast agent featuring a high number of magnetically equivalent ¹⁹F-nuclei in a single macromolecule, adequate fluorine nucleus mobility, and excellent w

SUBMITTER: Strasser P 

PROVIDER: S-EPMC10890119 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature