A Temporary Acrylic Soft Denture Lining Material Enriched with Silver-Releasing Filler-Cytotoxicity, Mechanical and Antifungal Properties
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ABSTRACT:
SUBMITTER: Chladek G
PROVIDER: S-EPMC10890124 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
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Project description:Cannabidiol (CBD), derived from the Cannabis plant, has shown potential in dentistry for its antimicrobial properties, particularly against oral bacteria. Denture-associated infections, a common issue among denture wearers, present a challenge in antimicrobial enhancements to poly(methyl methacrylate) (PMMA), the primary material for dentures due to its favorable physical and aesthetic qualities. To address this, researchers developed PMMA denture coatings infused with CBD nanoparticles. The CBD coatings were synthesized using UV curing and characterized via 1H NMR, SEM, and FTIR spectroscopies. Antimicrobial activity was assessed against Staphylococcus aureus, Escherichia coli, and Streptococcus agalactiae. CBD demonstrated significant bactericidal effects on Gram-positive bacteria with a minimum inhibitory concentration (MIC) of 2-2.5 µg/mL and a minimum bactericidal concentration (MBC) of 10-20 µg/mL but was ineffective against planktonic Gram-negative bacteria. However, biofilm studies revealed a 99% reduction in biofilm growth for both Gram-positive and Gram-negative bacteria on CBD-infused PMMA compared to standard PMMA. The CBD disrupted bacterial cell walls, causing lysis. Dissolution studies indicated effective release of CBD molecules, crucial for antimicrobial efficacy. This study highlights CBD's potential for antibiotic-free denture coatings, reducing dental biofilms and plaque formation, and improving oral health outcomes.
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Project description:Long-term soft denture lining (LTSDL) materials are used to alleviate the trauma associated with wearing complete dentures. Despite their established clinical efficacy, the use of LTSDLs has been limited due to the unfavorable effects of the oral environment on some of their mechanical and performance characteristics. The unresolved issue of LTSDL colonization by Candida albicans is particularly problematic. Silicone-based LTSDL (SLTSDL) materials, which are characterized by more stable hardness, sorption and solubility than acrylic-based LTSDLs (ALTSDLs), are currently the most commonly used LTSDLs. However, SLTSDLs are more prone to debonding from the denture base. Moreover, due to their limitations, the available methods for determining bond strength do not fully reflect the actual stability of these materials under clinical conditions. SLTSDL materials exhibit favorable viscoelastic properties compared with ALTSDLs. Furthermore, all of the lining materials exhibit an aging solution-specific tendency toward discoloration, and the available cleansers are not fully effective and can alter the mechanical properties of LTSDLs. Future studies are needed to improve the microbiological resistance of LTSDLs, as well as some of their performance characteristics.
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Project description:The processing and characterization of hybrid PMMA resin composites with nano-zirconia (ZrO2) and electrospun polystyrene (PS) polymer fibers were presented in this study. Reinforcement was selected with the intention to tune the physical and mechanical properties of the hybrid composite. Surface modification of inorganic particles was performed in order to improve the adhesion of reinforcement to the matrix. Fourier transform infrared spectroscopy (FTIR) provided successful modification of zirconia nanoparticles with 3-Methacryloxypropyltrimethoxysilane (MEMO) and bonding improvement between incompatible inorganic nanoparticles and PMMA matrix. Considerable deagglomeration of nanoparticles in the matrix occurred after the modification has been revealed by scanning electron microscopy (SEM). Microhardness increased with the concentration of modified nanoparticles, while the fibers were the modifier that lowers hardness and promotes toughness of hybrid composites. Impact test displayed increased absorbed energy after the PS electrospun fibers had been embedded. The optimized composition of the hybrid was determined and a good balance of thermal and mechanical properties was achieved.
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Project description:ObjectiveThis study evaluated the influence of silicon dioxide (SiO2) nanoparticles on the flexural strength of heat-polymerized denture base materials.BackgroundNanoparticles have been incorporated into the denture base materials in different proportions to enhance the mechanical properties. Recently, the incorporation of SiO2 nanoparticles at low concentrations has shown promising outcomes.Materials and methodsFollowing the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) protocol, this study was designed with the following focused question: "Does the addition of SiO2 nanoparticles improve the flexural strength of heat-polymerized acrylic resins?" The inclusion criteria included in-vitro studies that assessed the flexural strength of SiO2 nanoparticle-reinforced heat-polymerized acrylic denture base resins tested according to American Dental Association specifications. The database search involved articles published from 2005 to 2020 on PubMed/MEDLINE, Web of Science, Google Scholar, and Scopus using the following keywords: SiO2, nanosilica, silica oxide, nanoparticles, denture base resin, acrylic resin, polymethyl methacrylate, PMMA, flexural strength, and mechanical properties.ResultsAmong 167 studies, five papers fulfilled the inclusion criteria and were added for the data analysis and meta-analysis. Proportions of incorporated SiO2 nanoparticles ranged from 0.25% to 15% and the reported flexural strength values for the reinforced acrylic resin ranged from 41.25 MPa to 124.56 MPa. The meta-analysis revealed no significant effect on the flexural strength between the unmodified and the SiO2 nanoparticle-reinforced acrylic resin.ConclusionTherefore, No particular concentration of SiO2 nanoparticles could be recommended for heat-polymerized denture base reinforcement.
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Project description:Soft denture lining (SDL) are acrylic or silicone based materials that can be cured with heat or auto polymerization process, which is commonly used in removable prosthodontics to reline the intaglio (interior) surface of the denture. Loss of softness due to aging process is caused by loss of plasticizer and other soluble component. However, water sorption causes changes in structure and increased materials hardness, thus need frequent replacement of the materials. To extend the durability of the SDL, sealer coating (SC) was used. In this data, sealant coating acts as mechanical barrier to prevent water sorption and solubility of the chemical component to preserved material hardness. This article provides the data of sealant coating effect on hardness and water sorption of acrylic-based and silicone-based SDL materials was arranged in 4 test group: pristine and coated acrylic SDL and pristine silicone SDL and coated silicone SDL. Shore Hardness test was carried out using a Shore A Durometer and water sorption data were presented. Accordingly, the data was statistically analyzed for comparison using independent T-test for shore A hardness and water sorption.
| S-EPMC8122148 | biostudies-literature
Project description:Background. The aim of the present study was to evaluate the effect of Corega and 2.5% sodium hypochlorite cleansing agents on the shear and tensile bond strengths of GC soft liner to denture base. Methods. A total of 144 samples (72 samples for tensile and 72 for shear bond strength evaluations) were prepared. The samples in each group were subdivided into three subgroups in terms of the cleansing agent used (2.5% sodium hypochlorite, Corega and distilled water [control group]). All the samples were stored in distilled water, during which each sample was immersed for 15 minutes daily in sodium hypochlorite or Corega solutions. After 20 days the tensile and shear bond strengths were determined using a universal testing machine. In addition, a stereomicroscope was used to evaluate fracture modes. Data were analyzed with one-way ANOVA, using SPSS 16. Results. The results of post hoc Tukey tests showed significant differences in the mean tensile and shear bond strength values between the sodium hypochlorite group with Corega and control groups (P=0.001 for comparison of tensile bond strengths between the sodium hypochlorite and control groups, and P<0.001 for the comparison of tensile bond strengths between the sodium hypochlorite and Corega groups and the shear bond strengths between the sodium hypochlorite and Corega groups, and sodium hypochlorite and control groups).The majority of failures were cohesive in the control and Corega groups and cohesive/adhesive in the sodium hypochlorite group. Conclusion. Immersion of soft liners in Corega will result in longevity of soft liners compared to immersion in sodium hypochlorite solution and sodium hypochlorite solution significantly decreased the tensile and shear bond strengths compared to the control and Corega groups.
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Project description:The colonization of poly(methyl methacrylate) (PMMA) denture base materials by pathogenic microorganisms is a major problem associated with the use of prostheses, and the incorporation of antimicrobial fillers is a method of improving the antimicrobial properties of these materials. Numerous studies have demonstrated the initial in vitro antimicrobial effectiveness of this type of material; however, reports demonstrating the stability of these fillers over longer periods are not available. In this study, silver sodium hydrogen zirconium phosphate was introduced into the powder component of a PMMA denture base material at concentrations of 0.25%, 0.5%, 1%, 2%, 4%, and 8% (w/w). The survival rates of the gram-positive bacterium Staphylococcus aureus, gram-negative bacterium Escherichia coli and yeast-type fungus Candida albicans were established after fungal or bacterial suspensions were incubated with samples that had been previously stored in distilled water. Storage over a three-month period led to the progressive reduction of the initial antimicrobial properties. The results of this study suggest that additional microbiological tests should be conducted for materials that are treated with antimicrobial fillers and intended for long-term use. Future long-term studies of the migration of silver ions from the polymer matrix and the influence of different media on this ion emission are required.
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Project description:Background The study’s objective is to assess the adherence of C. albicans in different types of denture polymers and the effectiveness of eugenol and commercialized denture cleansers in the removal of C. albicans. Three types of denture base polymers (Lucitone® 199 (High-Impact PMMA), Impact® (conventional PMMA) and Eclipse® (UDMA)) and two hard denture reline materials (Kooliner® and Tokuyama® Rebase II Fast) were used in this study. Methods Three hundred samples were prepared (6 × 2 mm disc shape) and divided into five groups of denture polymers (n = 60) and further subjected into five treatment groups (Polident®, Steradent, distilled water, eugenol 5-minutes, and eugenol 10-min). Three samples were extracted from each treatment group for baseline data (n = 12). Baseline data were used to calculate the initial number of C. albicans adherence. A 0.5 ml immersion solution from each specimen was cultured on YPD agar and incubated for 48 h at 37 °C. Visible colonies were counted using a colony counter machine (ROCKER Galaxy 230). Results The result showed that the denture base polymer significantly affected the initial adherence (p = 0.007). The removal of C. albicans was also considerably affected by the denture base polymers and denture cleansers (p < 0.05). Lucitone®, Tokuyama®, and Kooliner® denture base polymers immersed for 3 min in eugenol showed the best results of removal. Discussion This study’s overall results showed that all denture polymers used as denture bases had an effect on C. albicans initial adherence and removal from the denture base, and eugenol is comparable to commercialised denture cleansers in reducing the number of attached C. albicans on denture base polymers.
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Project description:A new tobacco filler Standard Reference Material (SRM) has been issued by the National Institute of Standards and Technology (NIST) in September 2016 with certified and reference mass fraction values for nicotine, N-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and volatiles. The constituents have been determined by multiple analytical methods with measurements at NIST and at the Centers for Disease Control and Prevention, and with confirmatory measurements by commercial laboratories. This effort highlights the development of the first SRM for reduced nicotine and reduced tobacco-specific nitrosamines with certified values for composition.
| S-EPMC5687819 | biostudies-literature
Project description:BackgroundThe second rule of the 4Rs concept (Reduce, Reuse, Recycle, and Recover) was applied in this study using recycled acrylic resin to improve the hardness and study the effect of aging on the hardness of heat cured denture base resins.MethodForty heat-cured acrylic resin samples were prepared and divided into control and modified groups. The hardness was tested using a type D durometer hardness tester for evaluating the effect of the thermal aging process on the hardness in the control and modified groups. The samples were either subjected to thermal aging (the specimens thermo-cycled 10 cycles per day between 55°C and 5°C with a 30-s dwell time) or were not.ResultsThe mean difference in hardness between specimens with and without aging in the modified group increased with increasing concentrations of incorporated recycled acrylic resin. Independent samples t test revealed that the hardness values of modified groups with aging were significantly higher than in those without aging (p ≤ 0.05). ANOVA revealed that the modified group revealed a significant increase in hardness than that of the control group (p ≤ 0.05).ConclusionsRecycling and reuse of acrylic resins improved the hardness of denture base resins. The aging period significantly affected the hardness values of the control and modified groups.
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