Untargeted Plasma Metabolomic Profiling in Patients with Depressive Disorders: A Preliminary Study.

ABSTRACT: Depressive disorder is a multifactorial disease that is based on dysfunctions in mental and biological processes. The search for biomarkers can improve its diagnosis, personalize therapy, and lead to a deep understanding of the biochemical processes underlying depression. The purpose of this work was a metabolomic analysis of blood serum to classify patients with depressive disorders and healthy individuals using Compound Discoverer software. Using high-resolution mass spectrometry, blood plasma samples from 60 people were analyzed, of which 30 were included in a comparison group (healthy donors), and 30 were patients with a depressive episode (F32.11) and recurrent depressive disorder (F33.11). Differences between patient and control groups were identified using the built-in utilities in

SUBMITTER: Chernonosov AA 

PROVIDER: S-EPMC10890195 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature