Role of the osaA Gene in Aspergillus fumigatus Development, Secondary Metabolism and Virulence.

ABSTRACT: Aspergillus fumigatus is the leading cause of aspergillosis, associated with high mortality rates, particularly in immunocompromised individuals. In search of novel genetic targets against aspergillosis, we studied the WOPR transcription factor OsaA. The deletion of the osaA gene resulted in colony growth reduction. Conidiation is also influenced by osaA; both osaA deletion and overexpression resulted in a decrease in spore production. Wild-type expression levels of osaA are necessary for the expression of the conidiation regulatory genes brlA, abaA, and wetA. In addition, osaA is necessary for normal cell wall integrity. Furthermore, the deletion of osaA resulted in a reduction in the ability of A. fumigatus to a

SUBMITTER: Dabholkar A 

PROVIDER: S-EPMC10890407 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature