Astaxanthin Inhibits H₂O₂-Induced Excessive Mitophagy and Apoptosis in SH-SY5Y Cells by Regulation of Akt/mTOR Activation.

ABSTRACT: Oxidative stress, which damages cellular components and causes mitochondrial dysfunction, occurs in a variety of human diseases, including neurological disorders. The clearance of damaged mitochondria via mitophagy maintains the normal function of mitochondria and facilitates cell survival. Astaxanthin is an antioxidant known to have neuroprotective effects, but the underlying mechanisms remain unclear. This study demonstrated that astaxanthin inhibited H₂O₂-induced apoptosis in SH-SY5Y cells by ameliorating mitochondrial damage and enhancing cell survival. H₂O₂ treatment significantly reduced the levels of activated Akt and mTOR and induced mitophagy, while pretreatment with astaxanthin prevented H₂O₂-induced inhibition of

SUBMITTER: Yan T 

PROVIDER: S-EPMC10890442 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature