NAFLD Fibrosis Progression and Type 2 Diabetes: The Hepatic-Metabolic Interplay.

ABSTRACT: The bidirectional relationship between type 2 diabetes and (non-alcoholic fatty liver disease) NAFLD is indicated by the higher prevalence and worse disease course of one condition in the presence of the other, but also by apparent beneficial effects observed in one, when the other is improved. This is partly explained by their belonging to a multisystemic disease that includes components of the metabolic syndrome and shared pathogenetic mechanisms. Throughout the progression of NAFLD to more advanced stages, complex systemic and local metabolic derangements are involved. During fibrogenesis, a significant metabolic reprogramming occurs in the hepatic stellate cells, hepatocytes, and immune cells, engaging carbohydrate and lipid pathways to support the high-energy-requiring processes. The

SUBMITTER: Cernea S 

PROVIDER: S-EPMC10890557 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature