Clinical Impact of Comprehensive Molecular Profiling in Adolescents and Young Adults with Sarcoma.

ABSTRACT: Sarcomas are a heterogenous group of tumours that commonly carry poor prognosis with limited therapeutic options. Adolescents and young adults (AYAs) with sarcoma are a unique and understudied patient population that have only achieved modest survival gains compared to other groups. We present our institutional experience of AYAs with sarcoma who underwent comprehensive molecular profiling (CMP) via either large-panel targeted DNA sequencing or whole genome and transcriptome sequencing and evaluated the feasibility and clinical impact of this approach. Genomic variants detected were determined to be clinically relevant and actionable following evaluation by the Molecular Tumour Board. Clinicians provided feedback regarding the utility of testing three months after reporting. Twenty-five pa

SUBMITTER: Andrew EC 

PROVIDER: S-EPMC10890624 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature