Epigenetics in Knee Osteoarthritis: A 2020-2023 Update Systematic Review.

ABSTRACT: Osteoarthritis is a leading cause of disability in the world. The scientific literature highlights the critical importance of epigenetic regulatory effects, intertwined with biomechanical and biochemical peculiar conditions within each musculoskeletal district. While the contribution of genetic and epigenetic factors to knee OA is well-recognized, their precise role in disease management remains an area of active research. Such a field is particularly heterogeneous, calling for regular analysis and summarizing of the data that constantly emerge in the scientific literature, often sparse and scant of integration. The aim of this study was to systematically identify and synthesize all new evidence that emerged in human and animal model studies published between 2020 and 2023. This was necess

SUBMITTER: Caldo D 

PROVIDER: S-EPMC10890710 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature