Project description:Memory compensation strategies serve an important role in everyday functioning, especially in the face of cognitive decline. Research on the external memory compensation strategies employed by older adults has focused almost entirely on non-digital tools. Less is known about how memory compensation strategies might have changed due to the rapid and widespread uptake of digital technologies. In the current research, 208 younger adults and 114 older adults freely reported what internal or external memory strategy or tool they would use to accomplish 20 different everyday memory tasks. Participants' responses were coded as involving either internal (e.g. using a mnemonic) or external (e.g. writing a list) strategies, and then underwent further categorisation to classify types of internal and external strategies (e.g. digital or physical tool). Findings indicated that external strategies were much more prevalent than internal strategies for both younger and older adults, and that digital compensation strategies were prevalent for both age groups. There were age differences such that older adults reported more strategies overall, and were less likely to report digital tools, more likely to report physical tools, more likely to report environmental tools, and less likely to report social tools than younger adults. Positive attitudes to technology were associated with digital tool use for older but not younger participants. Findings are discussed in terms of existing theories and approaches to studying memory compensation strategies and cognitive offloading.
Project description:Social face evaluation is a common and consequential element of everyday life based on the judgement of trustworthiness. However, the particular facial regions that guide such trustworthiness judgements are largely unknown. It is also unclear whether different facial regions are consistently utilized to guide judgments for different ethnic groups, and whether previous exposure to specific ethnicities in one's social environment has an influence on trustworthiness judgements made from faces or facial regions. This registered report addressed these questions through a global online survey study that recruited Asian, Black, Latino, and White raters (N = 4580). Raters were shown full faces and specific parts of the face for an ethnically diverse, sex-balanced set of 32 targets and rated targets' trustworthiness. Multilevel modelling showed that in forming trustworthiness judgements, raters relied most strongly on the eyes (with no substantial information loss vis-à-vis full faces). Corroborating ingroup-outgroup effects, raters rated faces and facial parts of targets with whom they shared their ethnicity, sex, or eye color as significantly more trustworthy. Exposure to ethnic groups in raters' social environment predicted trustworthiness ratings of other ethnic groups in nuanced ways. That is, raters from the ambient ethnic majority provided slightly higher trustworthiness ratings for stimuli of their own ethnicity compared to minority ethnicities. In contrast, raters from an ambient ethnic minority (e.g., immigrants) provided substantially lower trustworthiness ratings for stimuli of the ethnic majority. Taken together, the current study provides a new window into the psychological processes underlying social face evaluation and its cultural generalizability. PROTOCOL REGISTRATION: The stage 1 protocol for this Registered Report was accepted in principle on 7 January 2022. The protocol, as accepted by the journal, can be found at: https://doi.org/10.6084/m9.figshare.18319244 .
Project description:An international sample of 2754 selfies uploaded to Instagram that form part of the Selfiecity (www.selfiecity.net) research project (selfies originating from Bangkok, Berlin, London, Moscow, New York, and Sao Paolo) were examined to assess the existence of facial prominence differences in depictions of males and females and the variability of facial prominence among cultures. Results show that gender stereotypical bias resulting in greater facial prominence in depictions of men is present in selfies. The control of image creation and selection for publication by the persons presented in the images do not diminish this gender based bias. Also, when gender is controlled, significant differences exist in facial prominence among different cultures. Comparisons with various socio-cultural indicators indicate possible correlations of gender stereotypical bias to self-expression values, freedom of choice, people's influence on government's decisions, protection of freedom of speech and people's influence on issues in the professional and communal environment. This research does not find a correlation of gender based bias in selfies with gender equality or inequality measures among cultures.
Project description:Emerging perspectives in neuroscience indicate that the brain functions predictively, constantly anticipating sensory input based on past experience. According to these perspectives, prediction signals impact perception, guiding and constraining experience. In a series of six behavioral experiments, we show that predictions about facial expressions drive social perception, deeply influencing how others are evaluated: individuals are judged as more likable and trustworthy when their facial expressions are anticipated, even in the absence of any conscious changes in felt affect. Moreover, the effect of predictions on social judgments extends to both real-world situations where such judgments have particularly high consequence (i.e., evaluating presidential candidates for an upcoming election), as well as to more basic perceptual processes that may underlie judgment (i.e., facilitated visual processing of expected expressions). The implications of these findings, including relevance for cross-cultural interactions, social stereotypes and mental illness, are discussed. (PsycINFO Database Record
Project description:Social judgments of faces are thought to be underpinned by two perceptual components: valence and dominance. Recent work using a standard key-press task to assess reward value found that these valence and dominance components were both positively related to the reward value of faces. Although bodies play an important role in human social interaction, the perceptual dimensions that underpin social judgments of bodies and their relationship to the reward value of bodies are not yet known. The current study investigated these issues. We replicated previous studies showing that valence and dominance underpin social judgments of faces and that both components are positively related to the reward value of faces. By contrast, social judgments of bodies were underpinned by a single component that reflected aspects of both perceived valence and perceived dominance and was positively correlated with the reward value of bodies. These results highlight differences in how observers process faces and bodies.
Project description:The FK506-binding protein 51 (FKBP51) has emerged as a key regulator of endocrine stress responses in mammals and as a potential therapeutic target for stress-related disorders (depression, post-traumatic stress disorder), metabolic disorders (obesity and diabetes) and chronic pain. Recently, FKBP51 has been implicated in several cellular pathways and numerous interacting protein partners have been reported. However, no consensus on the underlying molecular mechanisms has yet emerged. Here, we review the protein interaction partners reported for FKBP51, the proposed pathways involved, their relevance to FKBP51's physiological function(s), the interplay with other FKBPs, and implications for the development of FKBP51-directed drugs.
Project description:Mutations in KIF7, the gene that encodes a component of the kinesin complex of anterograde intraflagellar transport in the cilia, have been reported to cause a range of phenotypes including hydrolethalis, acrocallosal syndrome and Joubert syndrome. In a cohort of patients with various neurogenetic phenotypes, we identified novel KIF7 mutations in two families that span the known phenotypic spectrum of KIF7-related disorders. Surprisingly, we also identified a novel truncating KIF7 mutation in a third consanguineous family, in which the index presented with intellectual disability but no overt signs of ciliopathy, and his brain magnetic resonance imaging revealed an isolated dysgenesis of corpus callosum. This small cohort contributes novel pathogenic alleles of KIF7 and suggests that KIF7-related phenotypes can include isolated dysgenesis of corpus callosum with intellectual disability, thus expanding the range of phenotypes that warrant sequencing of this gene.
Project description:Time perception plays a fundamental role in people's daily life activities, and it is modulated by changes in environmental contexts. Recent studies have observed that attractive faces generally result in temporal dilation and have proposed increased arousal to account for such dilation. However, there is no direct empirical result to evidence such an account. The aim of the current study, therefore, was to clarify the relationship between arousal and the temporal dilation effect of facial attractiveness by introducing a rating of arousal to test the effect of arousal on temporal dilation (Experiment 1) and by regulating arousal via automatic expression suppression to explore the association between arousal and temporal dilation (Experiment 2). As a result, Experiment 1 found that increased arousal mediated the temporal dilation effect of attractive faces; Experiment 2 showed that the downregulation of arousal attenuated the temporal dilation of attractive faces. These results highlighted the role of increased arousal, which is a dominating mechanism of the temporal dilation effect of attractive faces.
Project description:Emotional mimicry, the imitation of others' emotion expressions, is related to increased interpersonal closeness and better interaction quality. Yet, little research has focused on the effect of face masks on emotional mimicry and none on (masked) child faces. To address this gap, we conducted an online experiment (N = 235, German sample, adult perceivers). Masks reduced emotion recognition accuracy for all expressions, except in the case of anger in masked child faces, where perceived anger was even increased. Perceived interpersonal closeness was reduced for masked happy and sad faces. For both child and adult expressers, masks reduced facial mimicry of happy expressions, with no mask effects for sadness and anger expression. A stronger mask effect on facial happiness mimicry of child faces was mediated by the degree of emotion recognition accuracy. Smiles shown by masked children were not recognized well, likely due to the absence of wrinkles around the eyes in child faces. Independent of masks, sadness shown by children was mimicked even more strongly than when shown by adults. These results provide evidence for facial mimicry of child expressions by adult perceivers and show that the effects of face masks on emotion communication may vary when children wear them.
Project description:Calreticulin from parasites and its vertebrate hosts share ~50% identity and many of its functions are equally conserved. However, the existing amino acid differences can affect its biological performance. Calreticulin plays an important role in Ca2+ homeostasis and as a chaperone involved in the correct folding of proteins within the endoplasmic reticulum. Outside the endoplasmic reticulum, calreticulin is involved in several immunological functions such as complement inhibition, enhancement of efferocytosis, and immune upregulation or inhibition. Several parasite calreticulins have been shown to limit immune responses and promote infectivity, while others are strong immunogens and have been used for the development of potential vaccines that limit parasite growth. Furthermore, calreticulin is essential in the dialogue between parasites and hosts, inducing Th1, Th2 or regulatory responses in a species-specific manner. In addition, calreticulin participates as initiator of endoplasmic reticulum stress in tumor cells and promotion of immunogenic cell death and removal by macrophages. Direct anti-tumoral activity has also been reported. The highly immunogenic and pleiotropic nature of parasite calreticulins, either as positive or negative regulators of the immune response, render these proteins as valuable tools to modulate immunopathologies and autoimmune disorders, as well as a potential treatment of neoplasms. Moreover, the disparities in the amino acid composition of parasite calreticulins might provide subtle variations in the mechanisms of action that could provide advantages as therapeutic tools. Here, we review the immunological roles of parasite calreticulins and discuss possible beneficial applications.