StressME: Unified computing framework of Escherichia coli metabolism, gene expression, and stress responses.

ABSTRACT: Generalist microbes have adapted to a multitude of environmental stresses through their integrated stress response system. Individual stress responses have been quantified by E. coli metabolism and expression (ME) models under thermal, oxidative and acid stress, respectively. However, the systematic quantification of cross-stress & cross-talk among these stress responses remains lacking. Here, we present StressME: the unified stress response model of E. coli combining thermal (FoldME), oxidative (OxidizeME) and acid (AcidifyME) stress responses. StressME is the most up to date ME model for E. coli and it reproduces all published single-stress ME models. Additionally, it includes refined rate constants to improve prediction accuracy for wild-type and stress-evolved strains. StressME reveale

SUBMITTER: Zhao J 

PROVIDER: S-EPMC10890762 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature