Effect of antipsychotic drugs on group II metabotropic glutamate receptor expression and epigenetic control in postmortem brains of schizophrenia subjects.

ABSTRACT: Antipsychotic-induced low availability of group II metabotropic glutamate receptors (including mGlu₂R and mGlu₃R) in brains of schizophrenia patients may explain the limited efficacy of mGlu_2/3R ligands in clinical trials. Studies evaluating mGlu_2/3R levels in well-designed, large postmortem brain cohorts are needed to address this issue. Postmortem samples from the dorsolateral prefrontal cortex of 96 schizophrenia subjects and matched controls were collected. Toxicological analyses identified cases who were (AP+) or were not (AP-) receiving antipsychotic treatment near the time of death. Protein and mRNA levels of mGlu₂R and mGlu₃R, as well as GRM2 and GRM3 promoter-attached histone posttranslational modifications, were qu

SUBMITTER: DelaCuesta-Barrutia J 

PROVIDER: S-EPMC10891050 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature