Ferroptotic alveolar epithelial type II cells drive T_H2 and T_H17 mixed asthma triggered by birch pollen allergen Bet v 1.

ABSTRACT: Asthma is a common allergic disease characterized by airway hypersensitivity and airway remodeling. Ferroptosis is a regulated death marked by iron accumulation and lipid peroxidation. Several environmental pollutants and allergens have been shown to cause ferroptosis in epithelial cells, but the relationship between birch pollinosis and ferroptosis in asthma is poorly defined. Here, for the first time, we have identified ferroptosis of type II alveolar epithelial cells in mice with Bet v 1-induced asthma. Further analysis revealed that treatment with ferrostatin-1 reduced T_H2/T_H17-related inflammation and alleviated epithelial damage in mice with Bet v 1-induced asthma. In addition, ACSL4-knocked-down A549 cells are more resistant to Bet v 1-induced ferroptosis. Anal

SUBMITTER: Ma L 

PROVIDER: S-EPMC10891108 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature