Neutralizing antibodies after the third COVID-19 vaccination in healthcare workers with or without breakthrough infection.

ABSTRACT:

Background

Vaccinations against the SARS-CoV-2 are still crucial in combating the ongoing pandemic that has caused more than 700 million infections and claimed almost 7 million lives in the past four years. Omicron (B.1.1.529) variants have incurred mutations that challenge the protection against infection and severe disease by the current vaccines, potentially compromising vaccination efforts.

Methods

We analyzed serum samples taken up to 9 months post third dose from 432 healthcare workers. Enzyme-linked immunosorbent assays (ELISA) and microneutralization tests (MNT) were used to assess the prevalence of vaccine-induced neutralizing antibodies against various SARS-CoV-2 Omicron variants.

Results

In this serological analysis we show that SARS-CoV-2 vaccine combinati

SUBMITTER: Reinholm A 

PROVIDER: S-EPMC10891120 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature