A multi-cohort study of the hippocampal radiomics model and its associated biological changes in Alzheimer's Disease.

ABSTRACT: There have been no previous reports of hippocampal radiomics features associated with biological functions in Alzheimer's Disease (AD). This study aims to develop and validate a hippocampal radiomics model from structural magnetic resonance imaging (MRI) data for identifying patients with AD, and to explore the mechanism underlying the developed radiomics model using peripheral blood gene expression. In this retrospective multi-study, a radiomics model was developed based on the radiomics discovery group (n = 420) and validated in other cohorts. The biological functions underlying the model were identified in the radiogenomic analysis group using paired MRI and peripheral blood transcriptome analyses (n = 266). Mediation analysis and external validation were applied to further validate the

SUBMITTER: Xia H 

PROVIDER: S-EPMC10891125 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature