SNAT2-mediated regulation of estrogen and progesterone in the proliferation of goat mammary epithelial cells.

ABSTRACT: The development of the goat mammary gland is mainly under the control of ovarian hormones particularly estrogen and progesterone (P₄). Amino acids play an essential role in mammary gland development and milk production, and sodium-coupled neutral amino acid transporter 2 (SNAT2) was reported to be expressed in the mammary gland of rats and bovine mammary epithelial cells, which may affect the synthesis of milk proteins or mammary cell proliferation by mediating prolactin, 17β-estradiol (E₂) or methionine function. However, whether SNAT2 mediates the regulatory effects of E₂ and P₄ on the development of the ruminant mammary gland is still unclear. In this study, we show that E₂ and P₄ could increase the proliferation of goat

SUBMITTER: Jiang T 

PROVIDER: S-EPMC10891196 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature