Oral Candida carriage and resistance against common antifungal agents in hematopoietic stem cell transplantation recipients.

ABSTRACT:

Purpose

Allogeneic hematopoietic stem cell transplant (HSCT) recipients receiving long-term and high-dose immunosuppressive medications suffer commonly from oral candida infections. This prospective cohort study examined oral fungal carriage in HSCT recipients and screened the susceptibility against commonly used antifungal agents. An increasing oral occurrence of Candida spp. and the development of resistance against clinically administered fluconazole were hypothesized.

Methods

Two hundred HSCT recipients were included and followed up for 2 years post-HSCT. Oral microbiological specimens were analyzed with matrix-assisted laser desorption/ionization-time of flight mass spectrometry assays (MALDI-TOF). The colorimetric method was applied for the susceptibility testing by co

SUBMITTER: Mauramo M 

PROVIDER: S-EPMC10891237 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature