Distributed genetic effects of the corpus callosum subregions suggest links to neuropsychiatric disorders and related traits.

ABSTRACT:

Background

The corpus callosum (CC) is a brain structure with a high heritability and potential role in psychiatric disorders. However, the genetic architecture of the CC and the genetic link with psychiatric disorders remain largely unclear. We investigated the genetic architectures of the volume of the CC and its subregions and the genetic overlap with psychiatric disorders.

Methods

We applied multivariate genome-wide association study (GWAS) to genetic and T1-weighted magnetic resonance imaging (MRI) data of 40,894 individuals from the UK Biobank, aiming to boost genetic discovery and to assess the pleiotropic effects across volumes of the five subregions of the CC (posterior, mid-posterior, central, mid-anterior and anterior) obtained by FreeSurfer 7.1. Multivariate GWAS

SUBMITTER: Campbell ML 

PROVIDER: S-EPMC10891296 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature