Task-state skin potential abnormalities can distinguish major depressive disorder and bipolar depression from healthy controls.

ABSTRACT: Early detection of bipolar depression (BPD) and major depressive disorder (MDD) has been challenging due to the lack of reliable and easily measurable biological markers. This study aimed to investigate the accuracy of discriminating patients with mood disorders from healthy controls based on task state skin potential characteristics and their correlation with individual indicators of oxidative stress. A total of 77 patients with BPD, 53 patients with MDD, and 79 healthy controls were recruited. A custom-made device, previously shown to be sufficiently accurate, was used to collect skin potential data during six emotion-inducing tasks involving video, pictorial, or textual stimuli. Blood indicators reflecting individual levels of oxidative stress were collected. A discriminant model based

SUBMITTER: Lyu H 

PROVIDER: S-EPMC10891315 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature