Prediction for oxaliplatin-induced liver injury using patient-derived liver organoids.

ABSTRACT:

Background

Liver injury associated with oxaliplatin (L-OHP)-based chemotherapy can significantly impact the treatment outcomes of patients with colorectal cancer liver metastases, especially when combined with surgery. To date, no definitive biomarker that can predict the risk of liver injury has been identified. This study aimed to investigate whether organoids can be used as tools to predict the risk of liver injury.

Methods

We examined the relationship between the clinical signs of L-OHP-induced liver injury and the responses of patient-derived liver organoids in vitro. Organoids were established from noncancerous liver tissues obtained from 10 patients who underwent L-OHP-based chemotherapy and hepatectomy for colorectal cancer.

Results

Organoids cultured in a gal

SUBMITTER: Tatsumi K 

PROVIDER: S-EPMC10891453 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature