Are embryonic stem cell markers and ALDH1A1 relevant in the context of breast cancer estrogen positivity?

ABSTRACT:

Background

Embryonic pluripotency markers are recognized for their role in ER- BC aggressiveness, but their significance in ER+ BC remains unclear. This study aims to investigate the prevalence of expression of pluripotency markers in ER+ BC and their effect on survival and prognostic indicators.

Methods

We analyzed data of ER+ BC patients from three large cancer datasets to assess the expression of three pluripotency markers (NANOG, SOX-2, and OCT4), and the stem cell marker ALDH1A1. Additionally, we investigated associations between gene expression, through mRNA-Seq analysis, and overall survival (OS). The prevalence of mutational variants within these genes was explored. Using immunohistochemistry (IHC), we examined the expression and associations with clinicopathologic p

SUBMITTER: Mousa NA 

PROVIDER: S-EPMC10891463 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature