Dendritic Cells as a Therapeutic Strategy in Acute Myeloid Leukemia: Vaccines.

ABSTRACT: Dendritic cells (DCs) serve as professional antigen-presenting cells (APC) bridging innate and adaptive immunity, playing an essential role in triggering specific cellular and humoral responses against tumor and infectious antigens. Consequently, various DC-based antitumor therapeutic strategies have been developed, particularly vaccines, and have been intensively investigated specifically in the context of acute myeloid leukemia (AML). This hematological malignancy mainly affects the elderly population (those aged over 65), which usually presents a high rate of therapeutic failure and an unfavorable prognosis. In this review, we examine the current state of development and progress of vaccines in AML. The findings evidence the possible administration of DC-based vaccines as an adjuvant tr

SUBMITTER: Palomares F 

PROVIDER: S-EPMC10891551 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature