Evaluation of Porous (Poly(lactide-co-glycolide)-co-(ε-caprolactone)) Polyurethane for Use in Orthopedic Scaffolds.

ABSTRACT: To develop an orthopedic scaffold that could overcome the limitations of implants used in clinics, we designed poly(ester-urethane) foams and compared their properties with those of a commercial gold standard. A degradable poly(ester-urethane) was synthetized by polyaddition between a diisocyanate poly(ε-caprolactone) prepolymer (PCL di-NCO, M_n = 2400 g·mol^-1) and poly(lactic-co-glycolic acid) diol (PLGA, M_n = 2200 g·mol^-1) acting as a chain extender. The resulting high-molecular-weight poly(ester-urethane) (PEU, M_n = 87,000 g·mol^-1) was obtained and thoroughly characterized by NMR, FTIR and SEC-MALS. The porous scaffolds were then processed using the solvent casting (SC)/particle leaching (PL) me

SUBMITTER: Savin G 

PROVIDER: S-EPMC10891616 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature