New Library of Iodo-Quinoline Derivatives Obtained by an Alternative Synthetic Pathway and Their Antimicrobial Activity.

ABSTRACT: 6-Iodo-substituted carboxy-quinolines were obtained using a one-pot, three-component method with trifluoroacetic acid as a catalyst under acidic conditions. Iodo-aniline, pyruvic acid and 22 phenyl-substituted aldehydes (we varied the type and number of radicals) or O-heterocycles, resulting in different electronic effects, were the starting components. This approach offers advantages such as rapid response times, cost-effective catalysts, high product yields and efficient purification procedures. A comprehensive investigation was conducted to examine the impact of aldehyde structure on the synthesis pathway. A library of compounds was obtained and characterized by FT-IR, MS, ¹H NMR and ¹³C NMR spectroscopy and single-ray crystal diffractometry. Their antimicrobial ac

SUBMITTER: Al-Matarneh CM 

PROVIDER: S-EPMC10891861 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature