Design, Synthesis of Hydrogen Peroxide Response AIE Fluorescence Probes Based on Imidazo [1,2-a] Pyridine.

ABSTRACT: Hydrogen peroxide (H₂O₂), a significant member of reactive oxygen species, plays a crucial role in oxidative stress and cell signaling. Abnormal levels of H₂O₂ in the body can induce damage or even impair body function, leading to the development of certain diseases. Therefore, real-time monitoring of H₂O₂ in living cells is very important. In this work, the aggregation-induced emission fluorescence probe 2-(2-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) benzyl) oxy) phenyl) imidazo [1,2-a] pyridine (B2) was designed and synthesized, which enables the long-term tracing of H₂O₂ in living cells. The addition of H₂O₂ to probe B2 results in a dramatic fluorescence en

SUBMITTER: Tong L 

PROVIDER: S-EPMC10891862 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature