Bioavailability of Oral Curcumin in Systematic Reviews: A Methodological Study.

ABSTRACT: Curcumin is a natural compound found in turmeric that exhibits diverse biological activities. However, its poor bioavailability limits its therapeutic application, which has led to the development of various bioavailability-improved formulations. In this methodological study, we analyzed whether systematic reviews on curcumin considered the bioavailability of systemic oral curcumin formulations when synthesizing evidence from human clinical trials. A total of 171 systematic reviews published between 2003 and 2022 were included in the study. From the included studies, we extracted data on study characteristics; type of curcumin; methods; and reporting regarding bioavailability, funding, and conflict of interest. Our results show that systematic reviews rarely consider the variable bioavaila

SUBMITTER: Bucevic Popovic V 

PROVIDER: S-EPMC10891944 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature