Prodigiosin as an Antibiofilm Agent against the Bacterial Biofilm-Associated Infection of <i>Pseudomonas aeruginosa</i>.

ABSTRACT: Pseudomonas aeruginosa is known to generate bacterial biofilms that increase antibiotic resistance. With the increase of multi-drug resistance in recent years, the formulation of a new therapeutic strategy has seemed urgent. Preliminary findings show that Prodigiosin (PG), derived from chromium-resistant Serratia marcescens, exhibited efficient anti-biofilm activity against Staphylococcus aureus. However, its anti-biofilm activity against P. aeruginosa remains largely unexplored. The anti-biofilm activity of PG against three clinical single drug-resistant P. aeruginosa was evaluated using crystal violet staining, and the viability of biofilms and planktonic cells were also assessed. A model of chronic lung infection was constructed to test the in vivo ant

SUBMITTER: Ma Z 

PROVIDER: S-EPMC10891946 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature