IgD⁺IgM^- B Cells in Common Variable Immunodeficiency.

ABSTRACT: Common variable immunodeficiency (CVID) is the most frequent form of primary hypogammaglobulinemia in adults. In addition to recurrent infections and respiratory manifestations, CVID patients may present several non-infection complications such as autoimmune diseases. The mechanisms that lead to immune dysregulation in CVID are not completely understood. Given the role of IgD on naïve B cells in the maintenance of tolerance and secreted IgD in the respiratory mucosa, we evaluated the frequency of IgD⁺ naïve and IgD⁺ memory B cells in CVID patients. Here, no differences were observed in the percentages and proliferative responses of anergic IgD⁺IgM^-CD27^- B cells between CVID patients, with or without autoimmune disease, and the control

SUBMITTER: Kasahara TM 

PROVIDER: S-EPMC10891963 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature