Antibacterial Potential of Symmetrical Twin-Drug 3,6-Diaminoxanthones.

ABSTRACT: Global health faces a significant issue with the rise of infectious diseases caused by bacteria, fungi, viruses, and parasites. The increasing number of multi-drug resistant microbial pathogens severely threatens public health worldwide. Antibiotic-resistant pathogenic bacteria, in particular, present a significant challenge. Therefore, there is an urgent need to identify new potential antimicrobial targets and discover new chemical entities that can potentially reverse bacterial resistance. The main goal of this research work was to create and develop a library of 3,6-disubstituted xanthones based on twin drugs and molecular extension approaches to inhibit the activity of efflux pumps. The process involved synthesizing 3,6-diaminoxanthones through the reaction of 9-oxo-9H-xanthene-

SUBMITTER: Resende DISP 

PROVIDER: S-EPMC10891989 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature