RNA N⁶-Methyladenosine Affects Copper-Induced Oxidative Stress Response in Arabidopsis thaliana.

ABSTRACT: Recently, post-transcriptional regulation of mRNA mediated by N⁶-methyladenosine (m⁶A) has been found to have profound effects on transcriptome regulation during plant responses to various abiotic stresses. However, whether this RNA modification can affect an oxidative stress response in plants has not been studied. To assess the role of m⁶A modifications during copper-induced oxidative stress responses, m⁶A-IP-seq was performed in Arabidopsis seedlings exposed to high levels of copper sulfate. This analysis revealed large-scale shifts in this modification on the transcripts most relevant for oxidative stress. This altered epitranscriptomic mark is known to influence transcript abundance and translation; therefore we scrutinized these possibiliti

SUBMITTER: Sharma B 

PROVIDER: S-EPMC10892094 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature