Antibody-Dependent Respiratory Burst against <i>Plasmodium falciparum</i> Merozoites in Individuals Living in an Area with Declining Malaria Transmission.

ABSTRACT: Malaria transmission intensity affects the development of naturally acquired immunity to malaria. An absolute correlate measure of protection against malaria is lacking. However, antibody-mediated functions against Plasmodium falciparum correlate with protection against malaria. In children, antibody-mediated functions against P. falciparum decline with reduced exposure. It is unclear whether adults maintain antibody-mediated functions as malaria transmission declines. This study assessed antibody-dependent respiratory burst (ADRB) in individuals from an area with declining malaria transmission. In an age-matched analysis, we compare ADRB activity during high versus low malaria transmission periods. Age significantly predicted higher ADRB activity in the high (p < 0.00

SUBMITTER: Mutemi DD 

PROVIDER: S-EPMC10892224 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature