Novel PVA-Hyaluronan-Siloxane Hybrid Nanofiber Mats for Bone Tissue Engineering.

ABSTRACT: Hyaluronan (HA) is a natural biodegradable biopolymer; its biological functions include cell adhesion, cell proliferation, and differentiation as well as decreasing inflammation, angiogenesis, and regeneration of damaged tissue. This makes it a suitable candidate for fabricating nanomaterials with potential use in tissue engineering. However, HA nanofiber production is restricted due to the high viscosity, low evaporation rate, and high surface tension of HA solutions. Here, hybrids in the form of continuous and randomly aligned polyvinyl alcohol (PVA)-(HA)-siloxane nanofibers were obtained using an electrospinning process. PVA-HA fibers were crosslinked by a 3D siloxane organic-inorganic matrix via sol-gel that restricts natural hydrophilicity and stiffens the structure. The hybrid nanofi

SUBMITTER: Sanchez-Tellez DA 

PROVIDER: S-EPMC10892577 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature