Multivalent Epigraph Hemagglutinin Vaccine Protects against Influenza B Virus in Mice.

ABSTRACT: Influenza B virus is a respiratory pathogen that contributes to seasonal epidemics, accounts for approximately 25% of global influenza infections, and can induce severe disease in young children. While vaccination is the most commonly used method of preventing influenza infections, current vaccines only induce strain-specific responses and have suboptimal efficacy when mismatched from circulating strains. Further, two influenza B virus lineages have been described, B/Yamagata-like and B/Victoria-like, and the limited cross-reactivity between the two lineages provides an additional barrier in developing a universal influenza B virus vaccine. Here, we report a novel multivalent vaccine using computationally designed Epigraph hemagglutinin proteins targeting both the B/Yamagata-like and B/Vic

SUBMITTER: Petro-Turnquist E 

PROVIDER: S-EPMC10892733 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature