Phylogenetics, Epidemiology and Temporal Patterns of Dengue Virus in Araraquara, Sao Paulo State.

ABSTRACT: Dengue virus (DENV) is a prominent arbovirus with global spread, causing approximately 390 million infections each year. In Brazil, yearly epidemics follow a well-documented pattern of serotype replacement every three to four years on average. Araraquara, located in the state of São Paulo, has faced significant impacts from DENV epidemics since the emergence of DENV-1 in 2010. The municipality then transitioned from low to moderate endemicity in less than 10 years. Yet, there remains an insufficient understanding of virus circulation dynamics, particularly concerning DENV-1, in the region, as well as the genetic characteristics of the virus. To address this, we sequenced 37 complete or partial DENV-1 genomes sampled from 2015 to 2022 in Araraquara. Then, using also Brazilian and worldwide

SUBMITTER: de Souza CS 

PROVIDER: S-EPMC10892747 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature