Identification of Genes Associated with Resistance to Persulcatusin, a Tick Defensin from Ixodes persulcatus.

ABSTRACT: Antimicrobial peptides (AMPs) are present in a wide range of plants, animals, and microorganisms. Since AMPs are characterized by their effectiveness against emergent antibiotic-resistant bacteria, they are attracting attention as next-generation antimicrobial compounds that could solve the problem of drug-resistant bacteria. Persulcatusin (IP), an antibacterial peptide derived from the hard tick Ixodes persulcatus, shows high antibacterial activity against various Gram- positive bacteria as well as multidrug-resistant bacteria. However, reports on the antibacterial action and resistance mechanisms of IP are scarce. In this study, we spontaneously generated mutants showing increased a minimum inhibitory concentration (MIC) of IP and analyzed their cross-resistance to other AMPs and

SUBMITTER: Shimoda S 

PROVIDER: S-EPMC10892762 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature