Immunomodulatory Peptides as Vaccine Adjuvants and Antimicrobial Agents.

ABSTRACT: The underdevelopment of adjuvant discovery and diversity, compared to core vaccine technology, is evident. On the other hand, antibiotic resistance is on the list of the top ten threats to global health. Immunomodulatory peptides that target a pathogen and modulate the immune system simultaneously are promising for the development of preventive and therapeutic molecules. Since investigating innate immunity in insects has led to prominent achievements in human immunology, such as toll-like receptor (TLR) discovery, we used the capacity of the immunomodulatory peptides of arthropods with concomitant antimicrobial or antitumor activity. An SVM-based machine learning classifier identified short immunomodulatory sequences encrypted in 643 antimicrobial peptides from 55 foe-to-friend arthropods.

SUBMITTER: Hemmati S 

PROVIDER: S-EPMC10892805 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature