Cyclodextrin-Enabled Enantioselective Complexation Study of Cathinone Analogs.

ABSTRACT: The characteristic alkaloid component of the leaves of the catnip shrub (Catha edulis) is cathinone, and its synthetic analogs form a major group of recreational drugs. Cathinone derivatives are chiral compounds. In the literature, several chiral methods using cyclodextrins (CDs) have been achieved so far for diverse sets of analogs; however, a comprehensive investigation of the stability of their CD complexes has not been performed yet. To characterize the enantioselective complex formation, a systematic experimental design was developed in which a total number of 40 neutral, positively, and negatively charged CD derivatives were screened by affinity capillary electrophoresis and compared according to their cavity size, substituent type, and location. The functional groups responsi

SUBMITTER: Doharszky A 

PROVIDER: S-EPMC10893103 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature