Mechanical Characterization of Dissolving Microneedles: Factors Affecting Physical Strength of Needles.

ABSTRACT: Dissolving microneedles (MNs) are novel transdermal drug delivery systems that can be painlessly self-administered. This study investigated the effects of experimental conditions on the mechanical characterization of dissolving MNs for quality evaluation. Micromolding was used to fabricate polyvinyl alcohol (PVA)-based dissolving MN patches with eight different cone-shaped geometries. Axial force mechanical characterization test conditions, in terms of compression speed and the number of compression needles per test, significantly affected the needle fracture force of dissolving MNs. Characterization using selected test conditions clearly showed differences in the needle fracture force of dissolving MNs prepared under various conditions. PVA-based MNs were divided into two groups that show

SUBMITTER: Ando D 

PROVIDER: S-EPMC10893124 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature