Sex Differences under Vitamin D Supplementation in an Animal Model of Progressive Multiple Sclerosis.

ABSTRACT: A central role for vitamin D (VD) in immune modulation has recently been recognized linking VD insufficiency to autoimmune disorders that commonly exhibit sex-associated differences. Similar to other autoimmune diseases, there is a higher incidence of multiple sclerosis (MS) in women, but a poorer prognosis in men, often characterized by a more rapid progression. Although sex hormones are most likely involved, this phenomenon is still poorly understood. Oxidative stress, modulated by VD serum levels as well as sex hormones, may act as a contributing factor to demyelination and axonal damage in both MS and the corresponding preclinical models. In this study, we analyzed sex-associated differences and VD effects utilizing an animal model that recapitulates histopathological features of the p

SUBMITTER: Haindl MT 

PROVIDER: S-EPMC10893160 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature