Particulate Matter Induces Oxidative Stress and Ferroptosis in Human Lung Epithelial Cells.

ABSTRACT: Numerous toxicological studies have highlighted the association between urban particulate matter (PM) and increased respiratory infections and lung diseases. The adverse impact on the lungs is directly linked to the complex composition of particulate matter, initiating reactive oxygen species (ROS) production and consequent lipid peroxidation. Excessive ROS, particularly within mitochondria, can destroy subcellular organelles through various pathways. In this study, we confirmed the induction of ferroptosis, an iron-dependent cell death, upon exposure to an urban PM using RT-qPCR and signaling pathway analysis. We used KRISS CRM 109-02-004, the certified reference material for the analysis of particulate matter, produced by the Korea Research Institute of Standards and Science (KRISS). To

SUBMITTER: Ahn Y 

PROVIDER: S-EPMC10893167 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature