HIV-1 Drug Resistance Detected by Next-Generation Sequencing among ART-Naive Individuals: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

There are an increasing number of articles focused on the prevalence and clinical impact of pretreatment HIV drug resistance (PDR) detected by Sanger sequencing (SGS). PDR may contribute to the increased likelihood of virologic failure and the emergence of new resistance mutations. As SGS is gradually replaced by next-generation sequencing (NGS), it is necessary to assess the levels of PDR using NGS in ART-naïve patients systematically. NGS can detect the viral variants (low-abundance drug-resistant HIV-1 variants (LA-DRVs)) of virus quasi-species at levels below 20% that SGS may fail to detect. NGS has the potential to optimize current HIV drug resistance surveillance methods and inform future research directions. As the NGS technique has high sensitivity, it is highly

SUBMITTER: Ouyang F 

PROVIDER: S-EPMC10893194 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature