The NLRP3 Inflammasome Is Dispensable in Methicillin-Resistant Staphylococcus aureus Urinary Tract Infection.

ABSTRACT: The NLRP3 inflammasome is a cytoplasmic complex that senses molecular patterns from pathogens or damaged cells to trigger an innate immune defense response marked by the production of proinflammatory cytokines IL-1β and IL-18 and an inflammatory death called pyroptosis. The NLRP3 inflammasome is activated in the urinary tract by a variety of infectious and non-infectious insults. In this study, we investigated the role of the NLRP3 inflammasome by comparing the pathophysiology of methicillin-resistant Staphylococcus aureus (MRSA) ascending UTI in wild-type (WT) and Nlrp3^-/- mice. The difference in the bacterial burden detected in the urinary tracts of MRSA-infected WT and Nlrp3^-/- was not statistically significant at 6, 24, and 72 h post-infection

SUBMITTER: Paudel S 

PROVIDER: S-EPMC10893321 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature