A parametric additive hazard model for time-to-event analysis.

ABSTRACT:

Background

In recent years, the use of non- and semi-parametric models which estimate hazard ratios for analysing time-to-event outcomes is continuously criticized in terms of interpretation, technical implementation, and flexibility. Hazard ratios in particular are critically discussed for their misleading interpretation as relative risks and their non-collapsibility. Additive hazard models do not have these drawbacks but are rarely used because they assume a non- or semi-parametric additive hazard which renders computation and interpretation complicated.

Methods

As a remedy, we propose a new parametric additive hazard model that allows results to be reported on the original time rather than on the hazard scale. Being an essentially parametric model, survival, hazard and pr

SUBMITTER: Voeltz D 

PROVIDER: S-EPMC10893628 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature