Vancomycin and nisin-modified magnetic Fe₃O₄@SiO₂ nanostructures coated with chitosan to enhance antibacterial efficiency against methicillin resistant Staphylococcus aureus (MRSA) infection in a murine superficial wound model.

ABSTRACT:

Background

The objective of this research was to prepare some Fe₃O₄@SiO₂@Chitosan (CS) magnetic nanocomposites coupled with nisin, and vancomycin to evaluate their antibacterial efficacy under both in vitro and in vivo against the methicillin-resistant Staphylococcus. aureus (MRSA).

Methods

In this survey, the Fe₃O₄@SiO₂ magnetic nanoparticles (MNPs) were constructed as a core and covered the surface of MNPs via crosslinking CS by glutaraldehyde as a shell, then functionalized with vancomycin and nisin to enhance the inhibitory effects of nanoparticles (NPs). X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), field emission scanning electron microscope (FE-SEM), vibrating sample magnetom

SUBMITTER: Nasaj M 

PROVIDER: S-EPMC10893753 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature