Emergent Damped Oscillation Induced by Nutrient-Modulating Growth Feedback.

ABSTRACT: Growth feedback, the inherent coupling between the synthetic gene circuit and the host cell growth, could significantly change the circuit behaviors. Previously, a diverse array of emergent behaviors, such as growth bistability, enhanced ultrasensitivity, and topology-dependent memory loss, were reported to be induced by growth feedback. However, the influence of the growth feedback on the circuit functions remains underexplored. Here, we reported an unexpected damped oscillatory behavior of a self-activation gene circuit induced by nutrient-modulating growth feedback. Specifically, after dilution of the activated self-activation switch into the fresh medium with moderate nutrients, its gene expression first decreases as the cell grows and then shows a significant overshoot before it reach

SUBMITTER: Melendez-Alvarez J 

PROVIDER: S-EPMC10893968 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature