Causality between COVID-19 and multiple myeloma: a two-sample Mendelian randomization study and Bayesian co-localization.

ABSTRACT: Infection is the leading cause of morbidity and mortality in patients with multiple myeloma (MM). Studying the relationship between different traits of Coronavirus 2019 (COVID-19) and MM is critical for the management and treatment of MM patients with COVID-19. But all the studies on the relationship so far were observational and the results were also contradictory. Using the latest publicly available COVID-19 genome-wide association studies (GWAS) data, we performed a bidirectional Mendelian randomization (MR) analysis of the causality between MM and different traits of COVID-19 (SARS-CoV-2 infection, COVID-19 hospitalization, and severe COVID-19) and use multi-trait analysis of GWAS(MTAG) to identify new associated SNPs in MM. We performed co-localization analysis to reveal potential cau

SUBMITTER: Wang S 

PROVIDER: S-EPMC10894079 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature